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Are 3D mammograms better than standard imaging? A diverse study aims to find out_我的网站

一 |     Are 3D mammograms better than standard 2D imaging for catching advanced cancers?A clinical trial is recruiting thousands of volunteers — including a large number of Black women who face disparities in breast cancer death rates — to try to find out.People like Carole Stovall, a psychologist in Washington, D.C., have signed up for the study to help answer the question.“We all need a mammogram anyway, so why not do it with a study that allows the scientists to understand more and move closer to finding better treatments and ways of maybe even preventing it?” Stovall said.The underrepresentation of women and minorities in research is a long-simmering issue affecting health problems including Alzheimer’s disease, stroke and COVID-19. Trials without diversity lead to gaps in understanding of how new treatments work for all people. “Until we get more Black women into clinical trials, we can’t change the science. And we need better science for Black bodies,” said Ricki Fairley, a breast cancer survivor and advocate who is working on the issue.Black women are 40% more likely to die from breast cancer than white women and tend to be diagnosed younger. But it’s not clear whether 3D mammography is better for them, said Dr. Worta McCaskill-Stevens of the National Cancer Institute.“Are there populations for whom this might be important to have early diagnosis?" asked McCaskill-Stevens. "Or is it harmful,” causing too many false alarms or unneeded follow-up tests and treatments?McCaskill-Stevens, who is Black, leads NCI’s efforts to boost access to cancer research in minority and rural communities. She has joined the study herself.The newer 3D technique has been around for a decade, but there’s never been conclusive evidence that it's better than 2D at detecting advanced cancers. The screening technique combines multiple pictures of the breast taken from different angles to create a 3D-like image. Both 3D and 2D mammograms compress the breast and use low doses of radiation.Prior studies suggest that 3D finds more cancers than 2D, but catching more cancers doesn’t necessarily mean more lives saved. Some cancers missed by standard screening may not progress or need treatment. Previous studies did not randomly assign patients to a screening method, the gold standard for research.The notion “that if it’s new, it’s shiny, then it’s better,” isn’t necessarily true, McCaskill-Stevens said. “Until we have the evidence to support that, then we need well-designed randomized trials.”The trial has enrolled nearly 93,000 women so far with a goal of 128,000. The NCI-funded study is now running in Canada, South Korea, Peru, Argentina, Italy and 32 U.S. states. A site in Thailand will soon begin enrolling patients.“We added more international sites to enhance the trial’s diversity, particularly for Hispanic and Asian women,” said Dr. Etta Pisano, who leads the study. Overall, 42% of participants are Hispanic. As recruiting continues, enrolling Black women and other women of color will “absolutely” continue as a priority, Pisano said.Participants are randomly assigned to either 2D or 3D mammograms and are followed for several years. The number of advanced cancers detected by the two methods will be compared.At the U.S. study sites, 21% of study participants are Black women — that's higher than a typical cancer treatment study, in which 9% of participants are Black, McCaskill-Stevens said.The University of North Carolina has signed up more Black women than any other study site. Nearly a quarter of the nearly 3,000 women enrolled at UNC’s two locations are Black.“Women in North Carolina want to take part in something that’s bigger than them,” said Dr. Cherie Kuzmiak, who leads the UNC arm of the study. “They want this active role in helping determine the future of health care for women.”In Washington, D.C., word of mouth has led to successful recruiting. A chance encounter at her hair salon persuaded Stovall to join the research. While waiting for a hair appointment, she met Georgetown University cancer researcher Lucile Adams-Campbell. The two, both Black, started chatting.“She explained how important it was to get women of color into the program,” said Stovall, who jumped at the chance to catch up on her mammograms after the COVID-19 pandemic delayed screening for her and thousands of others.For Stovall, there was a personal reason to join the research. Her sister recently completed treatment for triple negative breast cancer, an aggressive type that affects Black women at higher rates than white women. Women ages 45 to 74 without a personal history of breast cancer are eligible for the study, which launched in 2017. Many women also are providing blood and cheek swab samples for a database that will be mined for insights.“It’s a dream that people had since the beginning of screening that we wouldn’t fit everybody into the same box,” Pisano said. The study's findings could “reduce disparities if we’re successful, assuming people have access to care.”Stovall, 72, had a brief scare when her mammogram, the traditional 2D type, showed something suspicious. A biopsy ruled out cancer.“I was extremely relieved,” Stovall said. “Everybody I know has heard from me about the need for them to go get a mammogram.”___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.。    Exactly 75 years ago Jawaharlal Nehru, one of the principal leaders of India’s independence movement in the 1930s and 1940s, was sworn in as prime minister of the Dominion of India and raised the national flag at the Red Fort in Delhi. Having brought an end to the colonial rule of the British Empire, the Indian leadership embraced the concept of "non-alignment" and "neutrality" and diversified its ties, seeking new partnerships. At the time, the Soviet Union emerged as a natural ally for the independent Indian state.,Nehru was attracted to Marxism and promoted the idea of evolutionary and inclusive socialism. Back in 1927, the would-be Indian prime minister visited the USSR for the first time together with his wife Kamala, younger sister Krishna, and his father Motilal Nehru, a leader of the Indian National Congress.,The trip was connected with the 10th Anniversary of the Great October Socialist Revolution, which was seen by Nehru and other Indian nationalists in "a very positive light," according to Dr. Anuradha Chenoy, professor of the Center for Russian and Central Asian Studies at Jawaharlal Nehru University.,The Soviet press extensively covered the Nehrus' visit to Moscow, hailing Motilal and Jawaharlal as prominent leaders of India’s freedom movement. Jawaharlal Nehru was received in the Kremlin by Mikhail Kalinin, chairman of the Central Executive Committee of the USSR. Having wrapped up his journey, the Indian politician wrote a booklet titled "Soviet Russia, some random sketches and impressions" (1928).,"Jawaharlal Nehru was influenced by Marxist and socialist thought to some extent, as he saw the need for state intervention for alleviating poverty, developing infrastructure and for development," says Dr. Chenoy. "He thus advocated and made policies to develop state- or public sector industries and also created a Planning Commission. Independent India's Second Plan was especially modeled around the Soviet planning system.",CC BY 2.0 / Public.Resource.Org / Photo 656          Pandit Jawaharlal Nehru at the mike. 20.7.47                    Pandit Jawaharlal Nehru at the mike. 20.7.47          CC BY 2.0 / Public.Resource.Org / Photo 656,USSR Helped India Lay the Groundwork for Industrialization,On January 26, 1950, India became a republic within the Commonwealth of Nations with Jawaharlal Nehru serving as the Republic of India's prime minister until May 27, 1964. During this period, the USSR and India started to deepen their ties, according to Dr. Chenoy.,"Soviet support was crucial for an underdeveloped and newly liberated country like India," the academic explains. "Since India wanted to develop as a 'mixed economy,' that is to have both a state and private sector, Western countries refused them any aid and assistance that India needed. So India turned to the Soviet Union. The Soviet Union assisted India in the creation of new steel plants and several infrastructure industries. They assisted in developing Indian science and technology institutions which laid the base for Indian development in later years.",Dr. Chenoy elaborates that in the 1950s, the USSR helped India lay the groundwork for the country's early industrialization, with the Asian giant then starting to receive Russian defense equipment and military hardware.,CC0 / / Indian Prime Minister Indira Gandhi (1917-1984) at the National Press Club, Washington, D.C. 1n 1966 Indian Prime Minister Indira Gandhi (1917-1984) at the National Press Club, Washington, D.C. 1n 1966CC0 / /,Indo-Soviet Treaty of Peace, Friendship and Cooperation,The Indian war with Pakistan in 1971 became a pivotal moment for Indo-Soviet relations, according to the Indian academic. The conflict erupted over the Bangladesh liberation movement in East Pakistan, which was accompanied by killings of the Bengalis – both Muslims and Hindus – by West Pakistani forces led by General Agha Muhammad Yahya Khan in March 1971.,As a result of the violence and instability caused by the onslaught in East Pakistan, an estimated 10 million Bengalis fled to India by May 1971, prompting Delhi to intervene. Judging from documents released in December 2002 by the National Security Archive (NSA), a US non-profit archival institution, US President Richard Nixon and National Security Advisor Henry Kissinger did nothing to curtail the West Pakistani repressions against Bengalis and backed General Yahya.,After India stepped in to shield the Bengalis, "not only did the United States publicly pronounce India as the aggressor in the war, but the US sent the nuclear aircraft carrier, USS Enterprise, to the Bay of Bengal, and authorized the transfer of US military supplies to Pakistan, despite the apparent illegality of doing so," according to the non-profit.,Moscow's help came in handy at the time: in August 1971, India and the USSR concluded the Indo-Soviet Treaty of Peace, Friendship and Cooperation that specified mutual strategic cooperation between the countries. The treaty sent a powerful signal to the US and its allies. Eventually, the conflict ended on December 16, 1971 with the military forces of West Pakistan that were in Bangladesh surrendering.,"The Indian war with Pakistan on the issue of the liberation of Bangladesh in 1971 was a very special moment of Soviet support since the US wanted to help its ally Pakistan," says Dr. Chenoy. "After this, the Treaty of Friendship signed between India and the USSR was very holistic and provided India with much technological and defense support. Since then the friendship has increased.",© Photo : Indian PM OfficeModi Putin MeetModi Putin Meet© Photo : Indian PM Office,India's Strategic Autonomy,The historic Indo-Soviet Treaty of Peace, Friendship and Cooperation was renewed for another 20 years on August 8, 1991. After the collapse of the USSR, Moscow and New Delhi replaced the accords with the 20-year Treaty of Indo-Russian Friendship and Cooperation in January 1993.,Although the dissolution of the USSR resulted in a temporary chill in Russo-Indian economic and trade relations, they were soon reshuffled and are continuing to develop regardless of sanctions imposed by the West, according to Dr. Chenoy.,Since the declaration of independence back in 1947, India has managed to achieve significant strategic autonomy. The country has been maintaining ties with various global powers in accordance with its own strategic plans.,Thus, in June 2022, Indian Foreign Minister Subrahmanyam Jaishankar made it clear at the GlobeSec 2022 Bratislava Forum that India would not copycat the West's anti-Russia policies in the wake of Moscow's special operation to demilitarize and de-Nazify Ukraine. He stressed that “the world cannot be that Euro-centric as it used to be in the past,” adding that India, which is one-fifth of the world’s population and the fifth-largest economy will be guided by its national interests in the first place.。

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